東京科学大学 · 医歯学総合研究科 · 准教授

研究关键词primary immunodeficiency・inborn errors of immunity・hematopoietic cell transplantation・XIAP deficiency・Wiskott-Aldrich syndrome・GATA2 deficiency・familial hemophagocytic lymphohistiocytosis・pediatric leukemia immunology

研究领域ゲノム生物学・分子生物学・胎児医学、小児成育学・遺伝学

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• Ikuo Okuchi, Akira Nishimura, Takahiro Kamiya, Makiko Sasaki, Motoi Yamashita, Akihiro Hoshino, Michiko Kajiwara, Takeshi Isoda, Hirokazu Kanegane, Tomohiro Morio, Masatoshi Takagi. Monitoring measurable residual disease in NUP98::NSD1-positive acute myeloid leukemia. Pediatr Int. 2025; 67 (1): e15859. ( PubMed , DOI )2025
• Dan Tomomasa, Masatoshi Takagi, Ryohei Watanabe, Ryosuke Wakatsuki, Satoshi Miyamoto, Akihiro Hoshino, Takahiro Kamiya, Takeshi Isoda, Anju Kobayashi, Kenjiro Kosaki, Fumiaki Sakura, Takaki Asano, Toru Uchiyama, Satoshi Okada, Tomohiro Morio, Hirokazu Kanegane. Prolonged diagnostic journey in delayed-onset adenosine deaminase deficiency. Clin Immunol. 2025.01; 270 110405. ( PubMed , DOI )2025
• Okuchi Ikuo, Nishimura Akira, Kamiya Takahiro, Sasaki Makiko, Yamashita Motoi, Hoshino Akihiro, Kajiwara Michiko, Isoda Takeshi, Kanegane Hirokazu, Morio Tomohiro, Takagi Masatoshi. Monitoring measurable residual disease in NUP98::NSD1-positive acute myeloid leukemia(タイトル和訳中) Pediatrics International. 2025; 67 (1): ped.15859. ( 医中誌 )2025
• Inoue, K; Tomomasa, D; Nakagama, Y; Takeuchi, H; Tanaka, Y; Tanimoto, K; Kamiya, T; Isoda, T; Takagi, M; Tanaka, K; Yoshifuji, K; Miwa, Y; Ohnishi, H; Okada, S; Mori, T; Yasuda, S; Kido, Y; Morio, T; Kanegane, H. Real-world experience of tixagevimab/cilgavimab prophylaxis in Japanese patients with immunodeficiency JOURNAL OF INFECTION AND CHEMOTHERAPY. 2025.02; 31 (2): ( PubMed , DOI )2025

• 非コードRNA転写によるエンハンサー活性制御と免疫不全症、発がんメカニズムの解明
• 制御領域の変異同定と非コードRNA転写・スーパーエンハンサー活性化機構の解明
• ノンコーディングRNAによるT細胞分化および発がん抑制制御機構の解明
• 抗体産生不全症解析を通したヒト免疫記憶機構の解明

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