東京科学大学 · 総合研究院

研究关键词colorectal cancer・pancreatic cancer microenvironment・ALS genetics・SCN1A encephalopathy・schizophrenia transcriptomics・ferroptosis signaling

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• Funayama, R; Wang, YJ; Hosogane, M; Kao, WC; Toyama, S; Ohira, M; Matsumoto, M; Aizawa, T; Kobayashi, M; Karasawa, H; Ohnuma, S; Nakayama, KI; Unno, M; Nakayama, K. Alternative Splicing of FBLN2 Generates a Prometastatic Extracellular Matrix in Gastrointestinal Cancers by Determining N-Glycosylation of Fibulin 2 GENES TO CELLS. 2025.05; 30 (3): ( PubMed , DOI )2025
• Ochiai, K; Shima, H; Tamahara, T; Sugie, N; Funayama, R; Nakayama, K; Kurosaki, T; Igarashi, K. Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions EMBO JOURNAL. 2024.05; 43 (10): 1947-1964. ( PubMed , DOI )2024
• Nishiyama, A; Niihori, T; Suzuki, N; Izumi, R; Akiyama, T; Kato, M; Funayama, R; Nakayama, K; Warita, H; Aoki, Y; Aoki, M. Updated Genetic Analysis of Japanese Familial ALS Patients Carrying SOD1 Variants Revealed Phenotypic Differences for Common Variants NEUROLOGY-GENETICS. 2024.12; 10 (6): e200196. ( PubMed , DOI )2024
• Naito, S; Kajiwara, T; Karasawa, H; Ono, T; Saito, T; Funayama, R; Nakayama, K; Ohnuma, S; Unno, M. Calreticulin exposure induced by anticancer drugs is associated with the p53 signaling pathway in colorectal cancer cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2024.11; 733 150665. ( PubMed , DOI )2024

• 腫瘍特異的マイクロエクソンのスプライシング制御による大腸がん転移機構の解明
• タンパク質シトルリン修飾酵素PADI2が大腸がんに果たす役割の解明
• ヒストンコードによる転写伸長速度制御機構の解明
• ヒストン修飾酵素の機能に関する網羅的スクリーニング

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