静岡県立大学 · 薬学研究院/薬学部 · 特任助教

研究关键词pregnane X receptor・constitutive androstane receptor・nuclear receptor pharmacology・ligand screening systems・transcriptional activation・hepatic stellate cells・rat CAR activators

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• Development of a strategy to identify and evaluate direct and indirect activators of constitutive androstane receptor in rats.
• Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by downregulating periostin expression.
• PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α.
• Helix 12 stabilization contributes to basal transcriptional activity of PXR.

• ジペプチド脂質を含む新規脂質ナノ粒子を用いたがんmRNAワクチンの機能評価
• 機能増強を目指した新規脂質ナノ粒子の開発研究及び機序解析

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