医療創生大学 · 薬学科/薬学部

研究关键词fluorescent probe・機能性糖鎖・可視化・原子間力顕微鏡・structural analysis・-oligo-saccharide library・inhibitor・functional oligo-saccharide

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• Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging. K. Suzuki, A. Ohtake, Y. Ito, O. Kanie, CHEMICAL COMMUNICATIONS 48(78) 9744-9746 (2012). N-Hexyl-4-aminobutyl glycosides in the structural and biological investigations of oligosaccharide. K. Suzuki, A. Tobe, S. Adachi, S. Daikoku, Y. Hasegawa, Y. Shioiri, M. Kobayashi, O. Kanie, Org. Biomol. Chem. 7(22) 4726-4733 (2009).2012
• Diastereomeric resolution directed towards chirality determination focussing on gas-phase energetics of coordinated sodium dissociation
• Analysis of behavior of sodiated sugar hemiacetals under low-energy collision-induced dissociation conditions and application to investigating mutarotation and mechanism of a glycosidase
• Synthesis of a fluorescently tagged sialic acid analogue useful for live-cell imaging

• 糖関連酵素阻害剤の研究
• 細胞内オルガネラにおける糖鎖修飾機構解明をめざしたゴルジ機能ミミックの創製
• Construction of a multi-purpose oligo-saccharide library
• Study on inhibitor of carbohydrate enzymes

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