Akita Prefectural University · Department of Applied Biological Science · 准教授

Research keywords生菌剤・オリゴ糖・微生物・酵素・抗菌剤

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• Role of Phe286 in the recognition mechanism of cyclomaltooligosaccharides (cyclodextrins) by Thermoactinomyces vulgaris R-47 α-amylase 2 (TVAII). X-ray structures of the mutant TVAIIs, F286A and F286Y, and kinetic analyses of the Phe286-replaced mutant TV
• Complex pattern of membrane type 1 matrix metalloproteinase shedding - Regulation by autocatalytic cell surface inactivation of active enzyme
• Comparison of primary structures and substrate specificities of two pullulan-hydrolyzing α-amylases, TVA I and TVA II, from Thermoactinomyces vulgaris R-47
• Enzymatic synthesis of novel branched sugar alcohols mediated by the transglycosylation reaction of pullulan-hydrolyzing amylase II (TVA II) cloned from Thermoactinomyces vulgaris R-47

• プルラン分解酵素の糖転移反応を用いたオリゴ糖合成とそれが腸内細菌増殖に与える影響
• ゲノム解読に基づく新規抗生物質生産放線菌の開発によるリグノセルロースの高度資源化
• 天然における異種微生物間の生存戦略の解明

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