Chiba University · Medical Mycology Research Center

Research keywordsDectin-1・Dectin-2・DCIR・pulmonary aspergillosis・C-type lectin receptors・innate antifungal immunity

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• Role of dectin-1 in the host defense to infection with Cryptococcus neoformans
• Bone marrow-derived cells are responsible for the development of autoimmune arthritis in human T cell leukemia virus type I-transgenic mice and those of normal mice can suppress the disease
• Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia.
• Rag2-deficient IL-1 receptor antagonist-deficient mice are a novel colitis model in which innate lymphoid cell-derived IL-17 is involved in the pathogenesis

• 創薬標的の探索を目指したＩＬ－１関連遺伝子改変マウスライブラリーの作製と解析
• 骨・軟骨の恒常性維持におけるケモカイン及びC型レクチンの役割の解明
• 自己免疫性関節炎発症におけるサイトカイン機能の解析
• 真菌感染防御機構の分子基盤

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