Chiba University · Graduate School of Pharmaceutical Sciences · 助教

Research keywordsnatural products chemistry・Streptomyces metabolites・total synthesis・biosynthetic gene clusters・radical SAM enzymes・cyclophane formation・monoterpenoid indole alkaloids・glucosinolate metabolism・Arabidopsis sulfur metabolism

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• Stereochemical reassignment of heronamide A, a polyketide macrolactam from Streptomyces sp.
• Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-Range Stereochemical Communication on the Biological Activity
• Chemical Interactions of Cryptic Actinomycete Metabolite 5-Alkyl-1,2,3,4-tetrahydroquinolines through Aggregate Formation
• Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines

• 組織破壊に依存しない植物グルコシノレートの新たな分解機構とその生理的意義の解明
• 特化代謝のリサイクル経路がもたらすC/N/S循環システムの理解
• 特異なラジカルSAM酵素によって修飾された新規ペプチド天然物の探索
• 側鎖構造に起因するグルコシノレートの多様な生理的役割の解明

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