Chubu University · Graduate School of Life and Health Sciences / College of Life and Health Sciences

Research keywordsガングリオシド・糖鎖・シアル酸

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• Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord.
• Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance.
• GD2 is a Crucial Ganglioside in the Signal Modulation and Application as a Target of Cancer Therapeutics.
• Differential roles of gangliosides in malignant properties of melanomas.

• 関節リウマチにおけるIgGシアル酸の意義と新規治療戦略
• 脳内環境におけるガングリオシド糖鎖の分別的役割の解明
• 癌関連糖鎖複合体の細胞膜上及び細胞外小胞の生成・分泌と作用における動的機能の解明
• 関節リウマチの自己抗体上の糖鎖改変による機能制御と新規治療戦略

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