Chubu University · Graduate School of Life and Health Sciences / College of Life and Health Sciences · 教授

Research keywordsglioma-derived exosomes・ganglioside GD2・ganglioside GD3・melanoma malignancy・integrin signaling・Siglec-7 immune evasion・extracellular vesicles・glycolipid-enriched microdomains

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• Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains.
• Ganglioside GD3 Promotes Cell Grouth and Invasion through p130 Cas and Paxillin in Malignan Melanoma Cells
• Differential roles of gangliosides in malignant properties of melanomas.
• Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells.

• 微小環境因子による炎症反応と癌関連糖鎖合成酵素遺伝子の発現誘導機構及び意義の解明
• 癌関連スフィンゴ糖脂質と膜分子間の相互作用の時空間的動態と癌性形質増強機構の解析
• 癌関連糖鎖を含む脂質ラフトと細胞外分泌小胞の組成及びその微小環境の制御機能の解析
• 癌関連糖鎖複合体の細胞膜上及び細胞外小胞の生成・分泌と作用における動的機能の解明

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