Chubu University · Graduate School of Applied Biology / Faculty of Applied Biology · 教授

Research keywordscholesterol efflux・ABCA1 biology・lipoprotein metabolism・macrophage lipids・SREBP2 pathway・steroid effects

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• Involvement of caveolin-1 in cholesterol enrichment of high density lipoprotein during its assembly by apolipoprotein and THP-1 cells
• Differential regulation of apolipoprotein A-I/ATP binding cassette transporter A1-mediated cholesterol and phospholipid release.
• ApoA-I enhances generation of HDL-like lipoproteins through interaction between ABCA1 and phospholipase C gamma in rat astrocytes
• Calpain-mediated ABCA1 degradation: post-translational regulation of ABCA1 for HDL biogenesis.

• 細胞コレステロール搬出メカニズムの分子生物学的な解析〜アポリポタンパク質レセプターの同定・CDNAクローニングと機能の解析〜
• アポリポ蛋白質受容体刺激による細胞コレステロール搬出促進効果の評価モデルの確立
• 脳内HDLの機能;脳コレステロール輸送と障害の修復
• 加齢黄斑変性の病態におけるブルッフ膜への加齢性沈着脂質の役割の解明

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