Daiichi University of Pharmacy · Department of Pharmacy / Faculty of Pharmaceutical Sciences · 准教授

Research keywords2型糖尿病・Bamboo・Orientin・Oxidative・Pharmacology・Traditional・Vitexin・medicine

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• Multitasking bamboo leaf-derived compounds in prevention of infectious, inflammatory, atherosclerotic, metabolic, and neuropsychiatric diseases.
• Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.
• Impact of transgenic overexpression of SH2-containing inositol 5 '-phosphatase 2 on glucose metabolism and insulin signaling in mice
• Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5 '-phosphatase 2) on insulin signaling and glucose metabolism in mice

• 漢方補腎剤がインスリンシグナル伝達を介した２型糖尿病病態回復に与える影響の検討
• 肥満症治療薬としての牛車腎気丸および六味丸の有用性とその機序の解明
• 老化促進マウスにおける牛車腎気丸によるインスリン抵抗性改善作用の検討
• リピッドホスファターゼＳＨＩＰ２全身及び骨格筋特異的発現トランスジェニックマウスを用いたインスリン抵抗性成因メカニズムの解明

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