Daiichi University of Pharmacy · Department of Pharmacy / Faculty of Pharmaceutical Sciences · 教授

Research keywordslipocalin-type prostaglandin D synthase・substrate recognition・product binding sites・NMR structural biology・isothermal titration calorimetry・prostaglandin J2 complexes・product release mechanism・catalytic pocket dynamics

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• Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase.
• Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase.
• NMR solution structure of lipocalin-type prostaglandin D synthase: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity.

• 脂質メディエーターによる脂肪細胞分化制御の分子基盤
• プロスタグランジンD_2産生調節による外傷性大脳皮質損傷の拡大防止と修復促進
• 骨髄由来サプレッサー細胞による免疫調節機構の解明と癌治療への応用
• プロスタグランジンD2の輸送と代謝に関する研究

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