Fukui Prefectural University · Faculty of Bioresources / Graduate School of Bioresources · 准教授

Research keywordsProtein Science・生物時計・動的構造変化・タンパク質・分子進化

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• 主な業績2022 · 1. Mukaiyama A*, Furuike Y, Yamashita E and Akiyama S, “Highly Sensitive Tryptophan Fluorescence Probe for detecting Rhythmic Conformational changes of KaiC in the Cyanobacterial Circadian Clock system”, Biochemical Journal 479, 1505-1515 (2022) ＊責任著者
• 2. Furuike Y#, Mukaiyama A#, Ouyang D, Ito-Miwa K, Simon D, Yamashita E, Kondo T and Akiyama S, “Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria”, Sci. Adv. 8, eabm8990 (2022). #共同筆頭著者2022 · 4. Abe J#, Hiyama TB#, Mukaiyama A#, Son S#, Mori T#, Saito S, Osako M, Wolanin J, Yamashita E, Kondo T and Akiyama S, “Atomic-scale Origins of Slowness in the Cyanobacterial Circadian Clock”, Science 349, 312-316 (2015). #共同筆頭著者
• 【著書】2015 · 2. 秋山 修志, 向山 厚、”時計タンパク質KaiCの概日性分子鼓動”, 実験医学 29, 1281-1284 (2011).
• Delineation of the conformational thermostability of hyperthermophilic proteins based on structural and biophysical analyses

• 時間タンパク質学：時を生み出すタンパク質特性の総括
• 時限機能付き薬剤輸送システムの開発
• 時間タンパク質学：生命の時間を宿す機能的KaiCホモログの探索技術の開発
• 溶液中における時計タンパク質KaiCの動態解析

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