Fukui Prefectural University · Faculty of Bioresources / Graduate School of Bioresources · 准教授

Research keywords二次代謝・一次代謝・微生物・天然物・農学・環境・食品

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• 1)Fumihito Hasebe, Kazuya Adachi, Kazuya Yamanaka, Tadao Oikawa, Chitose Maruyama, Yoshimitsu Hamano.: Constitutive and high gene expression in the diaminopimelate pathway accelerates ε-poly-L-lysine production in Streptomyces albulus. The Journal of Antibiotics Volume 76, Issue 9, 522-531 (2023)2023 · 3) Fumihito Hasebe, Kenichi Matsuda, Taro Shiraishi, Yushi Futamura, Takeshi Nakano, Takeo Tomita, Ken Ishigami, Hikari Taka, Reiko Mineki, Tsutomu Fujimura, Hiroyuki Osada, Tomohisa Kuzuyama & Makoto Nishiyama.: Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces. Nature Chemical Biology Volume 12, 967-972 (2016)
• 4) Yuko Kanemaru, Fumihito Hasebe, Takeo Tomita, Tomohisa Kuzuyama, Makoto Nishiyama.: Two ATP-Binding Cassette Transporters Involved in (S)-2-Aminoethyl-Cysteine Uptake in Thermus thermophilus. Journal of Bacteriology Volume 195, 3845–3853 (2013)2013
• CRISPR/Cas9-mediated disruption of the PYRROLIDINE KETIDE SYNTHASE gene reduces the accumulation of tropane alkaloids in Atropa belladonna hairy roots
• Catalytic Mechanism of Ancestral L-Lysine Oxidase Assigned by Sequence Data Mining

• メチオニン生合成酵素における新規フィードバック制御機構の解明
• 細菌における新規メチオニン生合成経路の解明
• メチオニン生合成における硫黄キャリアタンパク質利用の分子基盤解明
• 放線菌における新規メチオニン⽣合成経路の探索

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