Fukui Prefectural University · Faculty of Bioresources / Graduate School of Bioresources

Research keywordsUnfolded Protein・プロオキシダント能・抗酸化能・異常蛋白質・抗酸化

Research fieldsApplied biochemistry・Functional biochemistry・Biomolecular chemistry

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• Combination of Dsb coexpression and an addition of sorbitol markedly enhanced soluble expression of single-chain Fv in Escherichia coli.Biotechnol Bioeng.91(4):418-24. (2005):ヒト一本鎖抗体の組換え発現効率の改善に成功した例2005
• 論文2001 · Journal of Biological Chemistry 276. 14393-14399 (2001) :活性型ヒト神経成長因子の組換え発現に成功した例
• 4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity.
• Improvement of productivity of active form of glutamate racemase in Escherichia coli by coexpression of folding accessory proteins

• 蛋白質安定化による疾患予防を目指した、低プロオキシダント性抗酸化物質の探索
• 筋萎縮性側索硬化症のグリア細胞の分子病態の解明を通じた治療法の開発
• Biochemistry and Biotechnology of Unfolded Protein
• γグルタミルシステイン合成酵素の基質特異性に関する構造生物学的研究

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