Fujita Health University · Faculty of Medicine / Graduate School of Medicine · 准教授

Research keywordscancer cell invasion・cancer associated fibroblasts・glioblastoma chemoresistance・Girdin Akt signaling・cadherin mediated invasion・tumor angiogenesis・prognostic biomarkers

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• Significance of perivascular tumour cells defined by CD109 expression in progression of glioma
• REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response.
• Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma.
• 癌関連線維芽細胞においてAktシグナルの下流にあるGirdinがリン酸化されることにより腫瘍増大を引き起こす(Akt signaling in cancer-associated fibroblasts contributes to tumor progression via Girdin phosphorylation)

• 集団的移動によるがん細胞浸潤の分子機序の解明
• Connexin 43による上皮細胞層からの癌細胞排除制御機構の解明
• RFPによるLamin Aの分解制御機構とその腫瘍悪性化における意義の解析
• がん細胞の浸潤形態制御機構およびその意義の解明

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