Gifu University · Faculty of Applied Biological Sciences · 准教授

Research keywordsPET radiochemistry・carbon-11 labeling・microglia imaging・CSF1R ligands・RIPK1 imaging・HSP90 probes・brain pharmacokinetics・neuroinflammation biomarkers

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• Sasa veitchiiextract exhibits antitumor effect against murine pancreatic adenocarcinoma in vivo and in vitro
• Noradrenaline transporter PET reflects neurotoxin-induced noradrenaline level decrease in the rat hippocampus.
• 11C-labeling of 20(S)-protopanaxadiol, an aglycon of ginsenoside, based on the use of Pd(0)-mediated rapid C-[11C]methylation of boronic precursors.
• Mycophenolate mofetil reduces cell viability associated with the miR-205-PAX9 pathway in human lip fibroblast cells.

• 生体直交反応とPETを用いた生体内細胞トラッキング法の開発
• 神経保護活性漢方薬成分のPET分子プローブ化
• TLR4を標的とした18F標識DNAアプタマーによる神経炎症イメージング
• ミクログリアPETイメージングのアルツハイマー病における有効性評価

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