Gifu University · University Hospital

Research keywordstumor-infiltrating CD8 T cells・single-cell sequencing・lung cancer immunotherapy・cancer-testis antigens・T-cell receptors・malignant pleural effusion

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• Subxiphoid robot-assisted complete resection for postchemotherapy primary mediastinal yolk sac tumour.
• Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer.
• Candidate tumor-specific CD8+ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis.
• Functional and structural analysis of KK-LC-1-specific T cell receptors from patients with lung Cancer for immunotherapy.

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