Gifu University · United Graduate School of Drug Discovery and Medical Information Sciences · 准教授

Research keywordsフェロトーシス・アルドケト還元酵素・オートファジー・カルボニル還元酵素・プロテアソーム・プロテインホメオスタシス・予防医学・創薬・抗がん剤耐性・構造活性相関

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• Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme
• Canine aldo-keto reductase 1C3 (AKR1C3/PGFS) exhibits 17β/20α-hydroxysteroid dehydrogenase activity and is inhibited by trilostane.
• Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: Probing the subunit interface with site-directed mutagenesis
• Effects of ligand binding on the stability of aldo-keto reductases: Implications for stabilizer or destabilizer chaperones

• カルボニル化合物代謝酵素の網羅的解析によるカルボニルストレス防御系の解明
• カルボニルストレス防御系酵素の網羅的解析
• プロテアソーム機能代償機構の制御化合物の開発
• 抗がん剤耐性膵臓がんに対する新規治療薬の開発

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