Gifu University · Graduate School of Medical Sciences

Research keywordspain mechanisms・nociception・dorsal root ganglion・neuropathic pain・morphine tolerance・nitric oxide signaling・spinal dorsal horn

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• Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats
• Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn.
• Tumor necrosis factor-alpha induces expression of C/EBP-beta in primary afferent neurons following nerve injury
• Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury.

• レミフェンタニルによる逆説的痛覚過敏におけるWnt signalingの役割の解明
• オピオイドによる痒みの細胞内シグナル及びTRPA1－痒みシグナル連関の解明
• 化学遺伝学を用いた下降性疼痛抑制系の操作で慢性疼痛治療薬のシードを探す
• カルシウム感受性蛍光タンパクを用いたスライス及びin vivo脊髄イメージング

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