Gunma University · Center for Bioinformatics and Genomic Resources

Research keywordsepigenome editing・DNA methylation・dCas9 SunTag・embryo implantation・CRISPR methods・histone methylation

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• Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice, Takuro Horii , Sumiyo Morita , Shinjiro Hino , Yuko Hino , Hiroto S Fukushima , Ryosuke Kobayashi , Mika Kimura , Mitsuyoshi Nakao , Yoichi Mizukami Azusa Inoue , Izuho Hatada, 2025年12月25日, Nature Communications, 16, 1, 研究論文（学術雑誌）2025 · 論文
• The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells, Ryosuke Kobayashi, Yuki Tajika, Junki Kohmaru , Sumiyo Morita , Takuro Horii , Yoichi Mizukami , Shizu Aikawa , Yasushi Hirota , Izuho Hatada, 2024年08月08日, Cell Death Discov ., 10, 1, 3572024 · 論文
• Optimized Protocol for the Regulation of DNA Methylation and Gene Expression Using Modified dCas9-SunTag Platforms, Sumiyo Morita , Takuro Horii , Izuho Hatada, 2024年07月17日, Epigenome Editing, 155, 165, 研究論文（学術雑誌）2024 · 論文
• Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice, Ryosuke Kobayashi , Reika Kawabata-Iwakawa , Makoto Sugiyama, Tetsunari Oyama, Masato Ohtsuka, Takuro Horii, Sumiyo Morita, Masahiko Nishiyama, Izuho Hatada, 2023年01月01日, Int J Cancer, 152, 11, 2331, 23372023 · 論文

• 肥満は父性遺伝するのか？, 森田 純代, 国立研究開発法人科学技術振興機構, 基盤研究(C)(一般), 2016年04月, 2019年03月, 研究代表者, 競争的資金2016 · 共同研究・競争的資金等の研究課題

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