Hirosaki University · University Hospital

Research keywordsDown syndrome-related myeloid disorders・GATA1・KIT gene regulation・azacitidine・pediatric hematology・myeloid leukemia

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• Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms.2024 · 143 ( 25 ) 2627 - 2643 2024年06月
• Antileukemic effect of azacitidine, a DNA methyltransferase inhibitor, on cell lines of myeloid leukemia associated with Down syndrome.2024 · Experimental hematology 132 104179 2024年04月
• Early-onset Marfan syndrome with a novel missense mutation: A case report.2023 · 27 ( 6 ) 283 - 286 2023年06月
• Isolated Bone Recurrence of Medulloblastoma With MYCN Amplification and TP53 Loss: A Case Report.2022 · Journal of pediatric hematology/oncology 44 ( 2 ) e593 - e596 2022年03月

• ダウン症候群に伴う骨髄性白血病の分子機構の解明と分子標的療法の開発
• 骨髄微小残存病変に着目したランゲルハンス細胞組織球症の分子機構解明
• 小児がんに対する抗体療法を増強する革新的免疫細胞療法の開発
• 赤血球分化における転写因子IRX1の機能の解明

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