Hokkaido University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 准教授

Research keywordsCajal body・非膜オルガネラ・分子生物学・ケミカルバイオロジー・snRNP・pre-mRNAスプライシング

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• Balancing RNA processing and innate immune response: Possible roles for SMN condensates in snRNP biogenesis. (review)2025 · Biochimica et biophysica acta. General subjects, 1869, 3, 130764, 130764, 2025年03月,
• Identification of BAY61-3606 Derivatives With Improved Activity in Splicing Modulation That Induces Inclusion of Cassette Exons Similar to the Splicing Factor 3B Subunit 1 Mutation.2024 · Chemical biology & drug design, 2024年10月,
• Dissecting the role of SMN multimerization in its dissociation from the Cajal body using harmine as a tool compound2024 · Journal of Cell Science, 2024年09月,
• BAY61-3606 Alters snRNP Composition and Enhances Usage of Suboptimal Splice Acceptor Site.2023 · Biological & pharmaceutical bulletin, 46, 2, 147, 157, 2023年,

• 低分子化合物によるスプライス部位選択制御の分子機構解明と疾患原因変異への応用
• 網膜色素変性症を引き起こすスプライソソーム生成経路の異常とその調節機構の解明
• スプライソソーム形成障害を標的とした低分子薬の探索と解析
• 相分離構造体とプロリン異性化の連携機構の解析と可視化ツールの開発

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