Hokkaido University · Faculty of Pharmaceutical Sciences / Graduate School of Pharmaceutical Sciences · 准教授

Research keywordsnonribosomal peptide biosynthesis・chemoenzymatic peptide cyclization・penicillin-binding protein-type thioesterases・macrolactamization・hydrazine biosynthesis・nitrogen-nitrogen bond formation・biosynthetic gene clusters・marine toxin biosynthesis・cyclic peptide total synthesis

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• An atypical non-ribosomal peptide cyclase catalyzing homochiral coupling with cyclic amine nucleophile2026 · The Journal of Antibiotics, 2026年03月,
• A Pseudokinase Catalyzes Nitrile Formation in the Biosynthesis of a Potent Marine Toxin2026 · Angewandte Chemie International Edition, 2026年04月14日,
• High-throughput prediction of protein–protein interactions uncovers hidden molecular networks in biosynthetic gene clusters2025 · biorxiv, 2025年10月27日
• Diol as a New Pantetheine Surrogate for Chemoenzymatic Synthesis of Cyclic Peptides via Nonribosomal Peptide Cyclases2025 · Methods in Molecular Biology, 105, 121, Springer US, 2025年06月19日,

• 複雑修飾中分子の固相化学酵素合成
• 複雑修飾ペプチドのフロー生体触媒合成
• 新規ペプチド環化酵素ファミリーPBP-type TE における特異性発現メカニズムの解明
• 微生物－酵素触媒複合系によるバイオヒドラジン生産

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