Himeji Dokkyo University · Faculty of Pharmaceutical Sciences, Department of Clinical Pharmacy · 准教授

Research keywordsamyotrophic lateral sclerosis・hepatocyte growth factor signaling・synaptic plasticity・GABA_A receptor blockade・amyloid beta pathology・Alzheimer disease・proteomic profiling・prostaglandin D synthase・tauopathy parkinsonism

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• Overexpression of cyclooxygenase-2 stimulates amyloid β-peptide production in neuronal cells
• Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of Notch-HES signaling and enhancement of AP-2 beta function in brain-derived TE671 cells
• GABAA受容体アンタゴニストによる LTP 様疎通の誘発
• Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients

• 肝細胞増殖因子の筋萎縮性側策硬化症に対する機能解析と疾患治療への適用
• 運動ニューロンにおける神経栄養因子受容体の活性化とその制御機構の解析
• 脳膜神経相関の分子機構
• 多発性骨髄腫患者の初回治療薬を決定するバイオマーカーの同定と臨床的有用性の検討

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