Iwate Medical University · Faculty of Pharmaceutical Sciences · 教授

Research keywords歯周病・Structural Biology・多剤耐性菌・情報科学・抗菌薬・構造生物・構造生物学・生物物理・蛋白質

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• The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents.
• Three-dimensional structure of a cyclic-nucleotide phosphodiesterase from human brain.
• Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity
• Crystallization and preliminary X-ray crystallographic studies of an exo-beta-D-glucosaminidase from Trichoderma reesei

• プロトン輸送ATPaseを標的とする抗口腔病原細菌薬の開発
• 糖非発酵グラム陰性細菌由来ジペプチド産生酵素の創薬分子基盤
• 糖非発酵グラム陰性細菌のペプチド代謝系を標的とする抗菌薬
• ロイコトキシン―受容体相互作用に関する分子基盤の解明と新規歯周炎ワクチンの開発

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