Iwate Medical University · Faculty of Pharmaceutical Sciences · 教授

Research keywords薬理遺伝学・薬物動態学・癌化学療法（基礎）・毒性学・癌化学療法・3次元細胞塊・肝毒性・アリル炭化水素受容体

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• Genetic variations and haplotype structures of the ABCB1 gene in a japanese population: An expanded haplotype block covering the distal promoter region, and associated ethnic differences
• Decreased expression of cytochromes p450 1A2, 2E1, and 3A4 and drug transporters Na(+)-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients
• Thirty novel genetic variations in the SLC29A1 gene encoding human equilibrative nucleoside transporter 1 (hENT1).
• Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

• 癌原活性化に関与する内分泌ホルモン感受性スルホトランスフェラーゼ遺伝子の構造解明
• 薬物代謝酵素の欠損及び多型に起因する副作用発現の分子薬理学的解析
• 薬物動態と薬物応答性に関する遺伝的、非遺伝的機構
• 遺伝子コピー数多型に基づく薬物動態関連遺伝子の日本人における個人差解析法の開発

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