Iwate Medical University · Division of Drug Discovery and Medical Device Development · 教授

Research keywordscancer molecular biology・ovarian cancer・pancreatic cancer・Glypican-1・Annexin A4・antibody-drug conjugates・platinum resistance・cancer immunogene therapy

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• Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4.
• Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma
• Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
• Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon

• プロテオミクス手法による悪性黒色腫の新規癌抗原の同定と遠隔転移の抗体治療法の開発
• プロテオミクス手法による膵臓癌の抗体医薬品標的分子の同定と新規治療法の開発
• Glypican-1を標的とした抗体薬物複合体による食道癌新規治療法の開発
• プロテオーム解析による、重症気管支肺異形成を予測する新規バイオマーカーの同定

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