Iwate Medical University · Faculty of Pharmaceutical Sciences · 教授

Research keywordsPharmacokinetics・薬物動態学・Molecular Oncology・エピジェネティクス・分子腫瘍学・Epigenetics・大腸癌・胃がん

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• β‑naphthoflavone‑induced upregulation of CYP1B1 expression is mediated by the preferential binding of aryl hydrocarbon receptor to unmethylated xenobiotic responsive elements2021
• A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5 '-flanking region of rat cytochrome P450 (CYP) 3A1 gene
• Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas.
• Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas.

• 胚における血管網形成因子の同定と再生医学への応用
• ヒト腫瘍におけるミトコンドリア遺伝子変異の検討
• 腫瘍における染色体不安定化の分子機構の解明とその臨床応用
• 核内受容体AhRを介したストレス応答変動に関わるDNAメチル化修飾の新たな役割

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