Iwate Medical University · Faculty of Dentistry, Department of Pharmacology (Division of Pathophysiology) · 教授

Research keywordshistamine neuroscience・histamine methyltransferase・sleep wake regulation・receptor occupancy・behavioral pharmacology

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• Oral histidine intake improves working memory through the activation of histaminergic nervous system in mice.
• JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice
• A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer's Disease Mouse Model.
• Histamine elicits glutamate release from cultured astrocytes

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