Iwate Medical University · Faculty of Pharmaceutical Sciences · 教授

Research keywordsATP synthase・rotary catalysis・proton transport・vacuolar ATPase・GATA 6 regulation・curcumin inhibition・proton pumps・phytopolyphenols

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• Activation of the Sarcophaga lectin gene promoter by (A+T)-stretch binding protein
• Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells
• Proton pumping V-ATPase inhibitor bafilomycin A1 affects Rab7 lysosomal localization and abolishes anterograde trafficking of osteoclast secretory lysosomes
• Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment

• リソソーム分泌の共通原理とオルガネラ輸送に普遍的なメカニズムの解明
• 一分子観察による植物のプロトンポンプＶ－ＡＴＰａｓｅの細胞内ｐＨ恒常性維持機構
• プロトンポンプの構造的多様性により制御されるオルガネラ輸送の包括的理解
• プロトンポンプが関与するオルガネラ輸送の原理の解明

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