Iwate Medical University · Faculty of Pharmaceutical Sciences

Research keywordsLipid - Raft・Glucose Transporter・Cytoskeletone・Cell Membrane・細胞骨格・糖輸送タンパク質・生体膜・ラフト

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• Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor
• Differential localization of glucose transporter isoforms in non-polarized mammalian cells: distribution of GLUT1 but not GLUT3 to detergent-resistant membrane domains.
• IMU1003, an atrarate derivative, inhibits Wnt/β-catenin signaling.
• Clotrimazole inhibits the Wnt/β-catenin pathway by activating two eIF2α kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase.

• 糖輸送タンパク質を分子標的とした新規抗がん治療薬の探索研究
• 糖輸送タンパク質の細胞膜機能ドメインへの分子集合機構と機能発現

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