Iwate Medical University · Faculty of Pharmaceutical Sciences · 教授

Research keywordsSignal transduction・細胞接着・シグナル伝達・Cell adhesion・ケミカルバイオロジー

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• An alpha 4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells (vol 7, pg 343, 2005)
• Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts
• Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP–E2F1–DNA damage response pathway axis.
• JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M.

• レドクス制御を介した増殖停止に関与する細胞性因子の解析
• 細胞接着斑蛋白質Hic-5による接着シグナルの制御
• 細胞接着シグナルのレドクス制御機構
• がん抑制遺伝子産物TSLC1による膜輸送制御とその細胞増殖抑制への意義の解析

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