Jichi Medical University · Faculty of Medicine, Department of Internal Medicine · 講師

Research keywords杌㈠啓鍥犲瓙・鏍勯婁唬璎

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• High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways
• Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism
• P53 involvement in the pathogenesis of fatty liver disease
• Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity

• 栄養センサーPtx4のO-GlcNAc糖鎖修飾を起点とする脂肪性肝炎治療戦略
• 生体イメージングと転写複合体解析技術によるエネルギー代謝スイッチング機構の解明
• 生体イメージングによるKLF15発現調節解析を基盤とするアミノ酸シグナルの実体解明
• 核内受容体型転写因子LXRの分子修飾による生体での栄養代謝制御機構の解明

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