Jichi Medical University · Graduate School of Medicine / Faculty of Medicine · 教授

Research keywords心筋細胞・心筋症・幹細胞生物学・多能性幹細胞・分化・遺伝子治療・転写解析・ゲノム編集

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• Convergence of notch and b-catenin signaling induces arterial fate in vascular progenitors
• Efficient and Scalable Purification of Cardiomyocytes from Human Embryonic and Induced Pluripotent Stem Cells by VCAM1 Surface Expression
• ATM Inhibition Enhances Knock-in Efficiency by Suppressing AAV-Induced Activation of Apoptotic Pathways.
• Identification of Chemicals Inducing Cardiomyocyte Proliferation in Developmental Stage–Specific Manner With Pluripotent Stem Cells

• 心筋症に対する遺伝子治療効果の予測手法の開発と実証
• 治療応用を目指したヒトES・iPS細胞からの効率的心筋分化誘導法の確立
• 遺伝性心筋症モデルの作出とゲノム治療法の開発
• 足場の硬さによる心筋細胞の成熟メカニズムの解明

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