Jichi Medical University · Graduate School of Medicine · 教授

Research keywords血小板・ゲノム編集・第IX因子・第VIII因子・遺伝子治療・血友病

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• The combination of Asp519Val/Glu665Val and Lys1813Ala mutations in FVIII markedly increases coagulation potential
• Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B
• Comparison of gabexate mesilate and nafamostat mesilate for disseminated intravascular coagulation associated with hematological malignancies.
• Safety of intra-articular transplantation of lentivirally transduced mesenchymal stromal cells for haemophilic arthropathy in a non-human primate.

• 遺伝子治療による次世代血友病治療法の開発と非ヒト霊長類を用いた前臨床研究
• AAVベクター遺伝子治療/ゲノム編集治療/CAR-T療法に関する研究開発
• マイクロポート植え込み血友病Aマウスを用いた抗原特異的免疫寛容誘導機序の解明
• 血友病Ａインヒビター制御を目的とした人工多能性幹細胞の応用

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