Jichi Medical University · Unclassified · 助教

Research keywordsゼブラフィッシュ・電気生理学・電位依存性ホスファターゼ・X線結晶構造解析・イオンチャネル・生理学

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• Interaction between S4 and the phosphatase domain mediates electrochemical coupling in voltage-sensing phosphatase (VSP)
• Engineering voltage sensing phosphatase (VSP)
• Nonsubstrate PI(4,5)P2interacts with the interdomain linker to control electrochemical coupling in voltage-sensing phosphatase (VSP)
• Voltage- and Ca2+-inducible PLC activity for analyzing PI(4,5)P2 sensitivity of ion channels in Xenopus oocytes

• 電位感受性酵素VSPの膜環境マルチセンシング機構の解明
• X線結晶構造解析による電位感受性酵素VSPの分子メカニズム解明
• in vitroとin vivoの両面から迫るKv4カリウムチャネルの不活性化機構とその生理的意義

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