Jichi Medical University · Faculty of Medicine, Department of Internal Medicine · 教授

Research keywordsrheumatoid arthritis・synovial fibroblasts・interleukin 6・interleukin 17・osteoclastogenesis・histone acetylation・neutrophil chemoattractants

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• A significant induction of neutrophilic chemoattractants but not RANKL in synoviocytes stimulated with interleukin 17
• Marked induction of c-Maf protein during Th17 cell differentiation and its implication in memory Th cell development
• Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation.
• Immunopathological analysis of Erdheim-Chester disease with massive ascites

• キメラ培養系を利用したヒト破骨細胞共存培養分化系確立の試みと分化メカニズムの解析
• 破骨細胞分化における転写因子Nfatc1アイソフォームの機能解析

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