Jichi Medical University · Faculty of Medicine / Department of Physiology · 講師

Research keywordsamyloid nucleation・prefibrillar aggregates・transthyretin amyloid・terahertz spectroscopy・protein hydration・fibrinogen inhibition・Ras conformational dynamics・antimicrobial peptides

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• NMR based structure-activity relationship analysis of an antimicrobial peptide, thanatin, engineered by site-specific chemical modification: Activity improvement and spectrum alteration
• Femtosecond-Laser-Enhanced Amyloid Fibril Formation of Insulin
• Multistep growth of amyloid intermediates and its inhibition toward exploring therapeutic way: A case study using insulin B chain and fibrinogen
• Broadband dielectric spectroscopy from sub GHz to THz of hydrated lipid bilayer of DMPC

• 線維前駆中間体の解析を基軸としたアミロイド線維の伝播性および毒性の構造基盤の解明
• クライオ電子顕微鏡による中間体を起点としたアミロイド線維形成の高分解能観測
• アミロイド線維形成に関与する水和水ダイナミクスの解明
• 水和水ダイナミクスによって誘起されるタンパク質機能関連モードの観測

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