Jichi Medical University · Faculty of Medicine / Department of Physiology · 教授

Research keywordsHemoglobin allostery・Oxygen binding・Protein hydration dynamics・X-ray fluorescence holography・Resonance Raman・Amyloid precursors・Myoglobin metal sites・Protein crystallography

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• Novel insights into the ULK2-FIP200-AMPK-mediated regulation of autophagy and BCR::ABL degradation in chronic myeloid leukemia2025
• Analysis of β‐C‐terminal salt bridges in T‐state hemoglobin by trapping tertiary conformations in silica gels2025
• Effects of allosteric effectors on oxygen binding to crystals of hemoglobin in the R‐quaternary structure2025
• Development of serial X-ray fluorescence holography for radiation-sensitive protein crystals.2023

• ３つのレーザー励起によるX線１分子追跡法を用いたヘモグロビン動態の全貌決定2020
• ヘモグロビン結晶構造の半網羅的機能決定2019
• 働く最中のヘモグロビン分子内動態の原子レベル追跡2016
• ヘモグロビンの四次構造変化を許容する結晶を用いた時分割構造解析法の開拓2015

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