The Jikei University School of Medicine · Research Institute of Clinical Medicine · 助教

Research keywordssynaptic plasticity・memory formation・optogenetics・CAMK2A・channelrhodopsin・phospholipase C・oxytocin・behavioral tagging

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• A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity
• A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments
• Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory
• All-optical presynaptic plasticity induction by photoactivated adenylyl cyclase targeted to axon terminals

• 脳幹‐中脳‐辺縁系回路によるシナプス可塑性と情動行動のドーパミン依存的制御
• 興奮性シナプス入力の樹状突起内統合におけるグリア・ニューロン代謝連関の解明
• 入力統合によるシナプス可塑性と情動記憶制御のドパミン性修飾

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