The Jikei University School of Medicine · Graduate School of Medicine / Faculty of Medicine

Research keywordsBland・筋弛緩薬、構造活性相関、創薬・Garland・White

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• Phase III clinical trial comparing the efficacy and safety of adamgammadex with sugammadex for reversal of rocuronium-induced neuromuscular block. Comment on Br J Anaesth 2024; 132: 45-52.
• Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs.
• Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine
• Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat.

• 超短時間作用型非脱分極性筋弛緩薬の開発を目指した基礎的検証
• 拮抗薬を必要としない持続静注に適した新規筋弛緩薬の開発
• 中枢神経系に及ぼす筋弛緩薬の作用機序の解明

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