The Jikei University School of Medicine · Graduate School of Medicine / Faculty of Medicine

Research keywords1次繊毛・発がん・ゲノム不安定性・翻訳後修飾・Hedgehog・DNA損傷応答

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• Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase
• Dual-specificity tyrosine-regulated kinase 2 exerts anti-tumor effects by induction of G1 arrest in lung adenocarcinoma
• The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis
• Inhibition of protein kinase C delta leads to cellular senescence to induce anti‐tumor effects in colorectal cancer

• 膵癌細胞が免疫抑制環境を構築する新規レギュレーターの同定と革新的免疫療法の開発

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