The Jikei University School of Medicine · Graduate School of Medicine / Faculty of Medicine · 准教授

Research keywordspolyamines・RNA structure・RAN translation・ribosomal frameshifting・RNA aptamers・translation regulation

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• Polyamine metabolism as a regulator of cellular and organismal aging.2026
• eIF3g binding to GUCG boxes located in mRNA coding regions enhances translation of mild heat shock response genes in the yeast Saccharomyces cerevisiae.2026
• Polyamines enhance repeat-associated non-AUG translation from CCUG repeats by stabilizing the tertiary structure of RNA.2025
• Translation efficiency affects the sequence-independent +1 ribosomal frameshifting by polyamines.2020

• ポリアミン代謝の変化に基づく新規老化マーカーと抗老化物質の創出2025
• 加齢によるスペルミン分解活性化機構解明と新規抗老化物質の創出2022
• ポリアミンが誘導するリピート病の発症機構とその制御による病態抑制効果の解明2022
• 生体内ポリアミン誘導体を標的とするRNAプタマーの取得とその応用2015

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