The Jikei University School of Medicine · Graduate School of Medicine / Faculty of Medicine · 講師

Research keywordsリンパ球・DOHaD仮説・マクロファージサブタイプ・腸内細菌叢・腸管免疫・胸腺・子宮内胎児発育不全(FGR)・亜鉛

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• Intratracheal administration of cross‐linked water‐soluble acrylic acid polymer is associated with inducible bronchi‐related lymphoid tissue formation and allergic inflammation
• Exposure to tributyltin (TBT) via food during developmental stages after weaning or the exposure via the placenta and their dam’s milk, inhibits body weight gain and behaviors in rats
• The increases in relative mRNA expressions of inflammatory cytokines and chemokines in splenic macrophages from rats exposed to multi-walled carbon nanotubes by whole-body inhalation for 13 weeks
• Ingestion of Excess Zinc Augments the Osmotic Fragility of Red Blood Cells via An Increase in Oxidative Stress

• DOHaD(Developmental Origins of Health and Disease)仮説の新たなエビデンス－必須微量元素“亜鉛”欠乏が次世代の免疫に及ぼす影響の解析/亜鉛補充効果の探索
• 亜鉛欠乏の腸管免疫機構－バクテリアルトランスロケーションに着目した炎症惹起の解明
• 亜鉛欠乏に伴う免疫異常-DOHaD仮説：次世代モデルによる機序解明と亜鉛補充効果
• 粉じん吸入による間質性肺疾患（じん肺）の治療法の開発

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