The Jikei University School of Medicine · Graduate School of Medicine / Faculty of Medicine · 准教授

Research keywordspediatric hematology・acute lymphoblastic leukemia・imatinib resistance・telomerase activity・X linked adrenoleukodystrophy・pediatric lymphoma

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• Successful treatment of hepatosplenic T-cell lymphoma with fludarabine, high-dose cytarabine and subsequent unrelated umbilical cord blood transplantation.
• Cytostatic concentrations of anticancer agents do not affect telomerase activity of leukemic cells in vitro
• Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors
• 治療終了時の画像検査にて腫瘍残存を示唆され、経過観察している乳児神経芽細胞腫Stage 4の1女児例

• DNAチップを用いた白血病分化誘導機序に関する研究
• テロメレース阻害剤の網膜芽細胞腫に対する抗腫瘍効果
• 造血幹細胞移植に伴う移植細胞のテロメアDNAの変化と造血能に関する研究

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