The Jikei University School of Medicine · Graduate School of Medicine / Faculty of Medicine

Research keywordsgastric cancer・colorectal cancer・pancreatic cancer・photoimmunotherapy・near-infrared imaging・HER2-targeted therapy・TROP2 antibody・tumor immunology

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• Cancer neovasculature-targeted near-infrared photoimmunotherapy (NIR-PIT) for gastric cancer: different mechanisms of phototoxicity compared to cell membrane-targeted NIR-PIT.
• マウス潰瘍性大腸炎関連大腸癌に対する近赤外セラノスティクス内視鏡(Near-infrared theranostic molecular endoscopy in a murine model of colitis-associated colorectal cancer)
• Combination photoimmunotherapy with monoclonal antibodies recognizing different epitopes of human epidermal growth factor receptor 2: an assessment of phototherapeutic effect based on fluorescence molecular imaging.
• High blood levels of soluble OX40 (CD134), an immune costimulatory molecule, indicate reduced survival in patients with advanced colorectal cancer.

• 光反応性血管新生阻害剤による腫瘍選択的治療法の開発

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