Juntendo University · Graduate School of Medicine / Faculty of Medicine

Research keywordslysosomes・autophagy・Golgi pH homeostasis・N-glycosylation・cholesterol biosynthesis・neurodegeneration

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• Shuhei Takada, Nozomi Shinomiya, Gaoxin Mao, Hikaru Tsuchiya, Tomoaki Koga, Satoko Komatsu-Hirota, Yu-Shin Sou, Manabu Abe, Elena Ryzhii, Michitaka Suzuki, Mitsuyoshi Nakao, Satoshi Waguri, Hideaki Morishita, Masaaki Komatsu. KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions. EMBO Rep. 2025 ＊ Both authors contributed equally to this work.2025
• Sou YS, Yamaguchi J, Masuda K, Uchiyama Y, Maeda Y and Koike M. Golgi pH homeostasis stabilizes the lysosomal membrane through N-glycosylation of membrane proteins. Life Science Alliance. 20242024
• Ichimura Y, Sugiura Y, Katsuragi Y, Sou YS, Uemura T, Tamura N, Komatsu-Hirota S, Ueno T, Koike M, Waguri S and Komatsu M. Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia. eLife. 20242024
• Sou YS, Yamaguchi J, Kameda H, Masuda K, Maeda Y, Uchiyama Y, Koike M. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS Lett. 596, 2873-2888. 20222022

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