Juntendo University · Graduate School of Medicine / Faculty of Medicine

Research keywordspolyunsaturated fatty acids・lipid metabolism・NAFLD・microlipophagy・adrenal lipoma formation・omega-3 fatty acids・lipidomics・FADS1 FADS2

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• Ando M, Lee-Okada HC, Yokomizo T. Molecular Mechanisms by Which Polyunsaturated Fatty Acids Suppress the Pathogenesis and Progression of NAFLD. Yakugaku Zasshi, 2025, 145, 177-182 (Review) doi: 10.1248/yakushi.24-00177-2.2025
• Yanai S, Sasaki J, Lee-Okada HC, Takahashi F, Kikuchi Y, Morioka S, Yamamoto T, Yuguchi K, Oikawa M, Kajiho H, Baba T, Yokoyama C, Morohashi KI, Suzuki A, Yokomizo T, Sasaki T. Adrenal lipoma formation via PI(3,4,5)P3/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes. Proc Natl Acad Sci U S A, 2025, 122, e2510306122. doi: 10.1073/pnas.2510306122.2025
• Sakai R, Aizawa S, Lee-Okada HC, Hase K, Fujita H, Kikuchi H, Inoue YU, Inoue T, Kabuta C, Yokomizo T, Hashimoto T, Wada K, Mano T, Koyama-Honda I, Kabuta T. The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders. Cell Rep, 2025, 44, 115829. doi: 10.1016/j.celrep.2025.115829.2025
• Lee-Okada HC, Xue C, Yokomizo T. Recent advances on the physiological and pathophysiological roles of polyunsaturated fatty acids and their biosynthetic pathway. Biochim Biophys Acta Mol Cell Biol Lipids, 2025, 1870, 159564 (Review, Correspondence) doi: 10.1016/j.bbalip.2024.1595642024

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