Juntendo University · Graduate School of Medicine / Faculty of Medicine · 特任教授

Research keywordsParkinson disease・tauopathy・autophagy・lithium therapy・frontotemporal dementia・brain perfusion imaging・movement disorders・amyotrophic lateral sclerosis

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• Ishikawa KI, Motoi Y, Mizuno Y, Kubo SI, Hattori N. Effect of dose escalation in Parkinson7s patients with dementia receiving long-term donepezil treatment: an exploratory study. Psychogeriatrics. 20142014
• Motoi Y, Shimada K, Ishiguro K, Hattori N. Lithium and autophagy. ACS Chem Neurosci. 2014 Apr 16 2013年まで2014
• Shimada K, Motoi Y, Ishiguro K, Kambe T, Matsumoto S, Itaya M, Kunichika M, Mori H, Shinohara S, Chiba M, Mizuno Y, Ueno T, Hattori N. Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion. Neurobiol Dis. 46 2012 101-1082012
• Kamakagata K, Motoi Y, Shimogi K, Nakanishi A, Hori M, Mizuno Y, Hattori N, Aoki S. posterior hypoperfusion in Parkinson's disease and Parkinson's disease with dementia measured with arterial spin-labering MR imaging.J MRI 33:803-807 (2011)2011

• 神経変性疾患におけるタウ蛋白蓄積機構の解明と臨床診断への応用
• 髄液マーカーを用いた変性型認知症の多施設大規模臨床解析
• アルツハイマー病におけるタウ蛋白伝播機構の解明と治療ターゲットの研究
• 神経変性疾患・タウ蛋白蓄積症の診断法の実用化と病態解明

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